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Mitophagys dual role depends on stress severity: pathological mitophagy (e.g., via PINK1/Parkin) releases iron and promotes ferroptosis, whereas basal mitophagy maintains mitochondrial quality to suppress ROS (Chang et al., 2024)

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several clinical trials are ongoing evaluating the role of IGF-1R inhibition in modulating resistance mechanisms to target therapies

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For this reason, choosing and locating the correct gluteal injection site is an essential part of safe intramuscular injection practice

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