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Patients with early-stage ALD often suffer from malnutrition or infections due to protein damage, so nutritional therapy should be implemented, focusing on providing high-protein, low-fat diets while balancing vitamin and folic acid levels within the body ( As ALD progresses to severe alcoholic hepatitis and cirrhosis, treatment guidelines recommend adding hormonal therapy to the early-stage treatments to prevent and halt the progression of cirrhosis

The Wnt/-catenin pathway, essential for cell proliferation, differentiation, and tissue regeneration, also becomes less active with age, leading to decreased skin regeneration and collagen synthesis

That makes it an expensive and inefficient approach compared to topical or dermatological treatments with longer-lasting results

Ozkol 2016

May 31 2017;18(6)doi:10.3390/ijms18061170