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2010)(Fig

doi: 10.1007/s00335-021-09879-z 278 HolcombRJOuraSNozawaKKentKYuZRobertsonMJet al

Its level decreases with age (especially from the age of 45-50) and as the body's defence needs increase (immunity, liver detoxification, antioxidant defences...)

(147) showed that in ovo delivery of Lactobacillus -based synbiotics on e12 significantly changed methylation pattern of several hepatic genes related to metabolism