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This reaction requires -ketoglutarate, oxygen, and ascorbate (vitamin C) as cofactors and takes place in the mitochondria

2025;11:eadt4126

In detail, early transcranial magnetic stimulation studies in SMA types 2 and 3, employing threshold-tracking techniques and normalization of muscle responses to peripheral stimulation, quantified and showed preserved motor cortical output alongside disproportionately increased muscle responses to cortical stimulation, suggesting compensatory neuroplasticity [13]