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the homodimeric antibody thus generated may have increased complement-mediated cell killing and antibody- dependent cellular cytotoxicity (ADCC) (see, e.g., Caron et al

Moreover, molecular subtype discordances and changes, as well as genetic heterogeneity between the primary BC and BCBM, can significantly influence treatment and prognosis, 77 limiting the potential efficacy of targeted therapies that are based on the analysis of the primary tumour

In clinical trials for premenopausal women with hypoactive desire disorder (HSDD), bremelanotide significantly increased libido scores and reduced personal distress about low desire