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Additionally, impaired mitochondria disrupt cellular processes such as apoptosis and autophagy, further contributing to neuronal loss and pathology in these diseases ( 2.3 Oxidative stress Oxidative stress is another important process that occurs in neurodegeneration

Pritchard and Miller, 1993

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In a rodent model, the hemolytic anemia and porphyrin accumulation was inhibited by iron chelation and inhibitors of the first enzyme in the heme synthesis pathway, delta-aminolevulinic acid synthetase (Blouin et al 2020)