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On the other hand, AMPK often acts as an energy sensor and is antagonistic to PI3K/Akt

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IGFBP-4 is present in various brain regions and is critical in neural stem cell differentiation, cerebellar plasticity, and astrocytic microtubule function [114]

Moreover, by targeting ferroportin, miR-302a-3p can induce lipid peroxidation and iron overload, inhibit the growth and colony formation of lung cancer cells, and increase their sensitivity to CDDP and paclitaxel chemotherapy [153]

In both IRI and sepsis-induced AKI models, HMGB1 release by TECs has been implicated in the promotion of renal inflammation (Zhao et al., 2023)