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doi: 10.1124/pr.116.013227 84

The aged mouse study involved small sample sizes

(2025) 43:937954.e939

Polymer-based DDSs use synthetic (e.g., PLGA) or natural polymers (e.g., chitosan) to fabricate nanocapsules, hydrogels, or microneedle arrays, enabling prolonged drug release profiles particularly advantageous for chronic hyperuricemia management (Ng et al., 2022)

As Young remembers, 'We couldnt predict weight loss or weight gain with these drugs.' One of the challenges was that enhanced insulin secretion normally increases body weight