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Increasing the ionic strength caused an increase in the sedimentation and diffusion coefficients, but a decrease in the intrinsic viscosity and in the frictional ratio of the protein These results are compatible with the proteins having a conformation approaching that of a random-coil polypeptide, the volume occupied by the molecule being determined by electrostatic repulsion between the excess of negative charges (Smith and Winkler, 1967)

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Acute treatments: Non-steroidal anti-inflammatory drugs (NSAIDs) and/or mild analgesics such as acetaminophen, sometimes combined with caffeine Triptan drugs (eg, sumatriptan, rizatriptan) Other drugs such as ergot alkaloids, opioids, and corticosteroids Preventive treatments (generally for frequent recurring migraines): Blood pressure medications Tricyclic antidepressants Anticonvulsants What Dietary and Lifestyle Changes Can Be Beneficial for Migraine Headaches