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At neutral to alkaline pH (above 7), deamidation proceeds through a cyclic imide intermediate that produces a mixture of normal and isomerized products

Wang X, Peng J, Cai P et al (2024b) The emerging role of the gut microbiota and its application in inflammatory bowel disease

doi: 10.3389/fendo.2023.1080969 Received 26 October 2022 Accepted 31 January 2023 Published 21 February 2023 Volume 14 - 2023 Edited by Jeff M

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NDDS enable targeted delivery and controlled release of copper ions, thereby precisely inducing cuproptosis to enhance therapeutic efficacy while minimizing toxicity