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A review on antibacterial, antiviral, and antifungal activity of curcumin

Canonical Mode of c-Met Activation Pattern The canonical mode of c-Met activation involves the binding of HGF to c-Met, which induces homodimerization and autophosphorylation of the cytoplasmic domain of c-Met and then triggers downstream signaling pathways, including the mitogen-activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) (Gonzalez et al., 2017), phosphatidylinositol 3 kinase (PI3K) (Pascale et al., 2016), p-38 (Lee et al., 2003), and the Akt/protein kinase B (PKB) (Zhang et al., 2018c) pathways (Figure 2)

Int J Mol Sci (2020) 21(8):2958

Furthermore, heat stress can induce reorganization of the intestinal cytoskeleton and downregulate the expression of tight junction proteins between intestinal cells, further exacerbating intestinal barrier dysfunction in human intestinal epithelial Caco-2 cells [18]

Regarding the molecular signaling pathway that leads to cellular damage after exposure to OP compounds such as DZN, OP compound exposure activates the ERK, JNK, and p38-MAPK pathways, initiating oxidative stress and apoptosis across diverse tissues [23]