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Only one SAM binding site is observed in CBS filaments Each Bateman module, assembled from the tandem CBS-1 and CBS-2 motifs, contains, in principle, two ligand-binding sites (S1 and S2) related by dyad symmetry (Supplementary Fig

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In vitro, in vivo, and clinical applications of stem cells in IDD BMSCs BMSCs are non-hematopoietic stem cells in the bone marrow that possess self-renewal ability, multiple differentiation potential, and certain homing ability, and can enhance the survival and regeneration of IVD cells and prevent further deterioration of IDD [36]

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