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5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC50 value (IC50=1 M), and high cell membrane permeability (Table 5), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors

However, it is imperative to note that findings from animal models cannot be directly extrapolated to clinical trials in humans

Although their purposes are similar, their mechanisms, benefits, and usage differ