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The Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO-FUS) prospectively evaluated 4832 offspring aged 1014 years born to mothers enrolled in the original HAPO cohort

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Likewise, a 6-month treatment with NAC in EP patients reduced plasma soluble RAGE, increased prefrontal GABA levels, and enhanced cognitive function [58]

Both renal aging and DN display multiple common pathophysiological mechanisms, particularly the buildup of AGEs

doi: 10.1016/J.ACA.2019.02.036 180 PerrinL.SpinosiJ.ChaperonL.KabS.MoisanF.EbazA