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HIFs can regulate several factors including VEGF, pyruvate dehydrogenase kinase 1 (PDK1), insulin-like growth factor 2 (IGF-2), carbonic anhydrase 9, glucose transporter 1, 3 (GLUT1/3), which are involved in cell proliferation, survival, angiogenesis, pH regulation, and metabolism

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In the pivotal STRATUM trial, nearly 80% of individuals achieved the primary efficacy endpoint of Investigators Global Assessment (IGA) Success, with just over 50% reaching complete clearance at week 8

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Distinct from ThT, TPE-TPP exhibits a significant fluorescence enhancement and a shorter lag phase when monitoring -synuclein fibrillation