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Creatine is an amino acid that is usually present within muscle tissue and brains

Despite some factors and small molecules (compounds) being shown to improve myelination in cell cultures, as well as remyelination in animal models, no medication presenting convincing remyelinating capacity in humans has been approved for MS patients so far, with clemastine and analogs of thyroid hormone still having to complete phase III clinical trials 23,24,25,26

Furthermore these two reactions occur in the mitochondria, i.e., they also require Mg ++ chelated to ATP

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