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Due to its fundamental role in maintaining cellular homeostasis, glutathione remains one of the most widely studied endogenous molecules in redox biology and metabolic research

doi: 10.1111/j.1462-5822.2005.00606.x

Simple structural modifications converting a bona fide MDM2 PROTAC degrader into a molecular glue molecule: a cautionary tale in the design of PROTAC degraders

This suggests that metabolic rewiring via lipid pathways is a non-canonical mechanism by which the autophagy-ferroptosis balance is tilted toward tumor promotion