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In addition to excessive intake of dietary supplements, parenteral administration of vitamin B12 may be another cause of excess, which is likely associated with an immune system response to produce anti-TC II antibodies

Retrieved October 15, 2021

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Research published in Toxicology and Applied Pharmacology found that copper supplementation above 10mg daily (roughly 5 the RDA) can disrupt zinc homeostasis and trigger oxidative stress in hepatic tissue