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The reason they require injection rather than oral administration is straightforward biochemistry: the gastrointestinal tract degrades most therapeutic peptides before they can reach systemic circulation

Second, even taken at face value, an assay-specific potency ratio is not a measure of whole-organism effect: it does not mean Dihexa is millions of times more effective in a living brain, where absorption, distribution, and signaling context all differ

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Prednisolone, usually 40 mg daily for four weeks, remains the recommended treatment for SAH, though the ideal dose is still debated

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