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Neuroplastic changes induced by physical exercise have been thought to mainly involve the striatum and prefrontal cortex, as well as modulation in the release of DA, cytokines, and neurotrophic factors (such as the brain-derived neurotrophic factor), increased corticomotor excitability, improved connectivity in sensorimotor networks, and changes in DA receptor activity ( Hence, both exercise, especially moderate anaerobic physical exercise, and a healthy diet rich in plant-derived nutrients, can positively affect PD incidence and progression, by stimulating neurotrophic factors, altering the diversity of the gut microbiome, improving barrier permeability, and increasing the levels of SCFAs- producing bacteria (Raber and Sharpton, 2023)

These two amino acids, cysteine and homocysteine, contain the sulfur atom and are particularly important because they play a crucial role in various physiological processes [1, 2]

If too many free radicals build up, they create oxidative stress, which harms cells and speeds up aging

The pFOXO3-TA-Luc plasmid designed to measure the transcriptional activity of FOXO3a was purchased from Beyotime (Shanghai, China)