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6 Clinical relevance and translational potential of mtDNA monitoring The growing understanding of mtDNAs role in HIV pathogenesis and ART-related toxicity has stimulated interest in its value as a clinically actionable biomarker

60 , 61 In addition, TH plays a role in regulating other mitochondrial enzymes important for oxidative processes such as pyruvate dehydrogenase kinase 4 ( PDK4 ), uncoupling protein 2 ( UCP2 ), acyl-CoA thioesterase 2, and acyl-CoA oxidase 1

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It is worth mentioning that ginsenoside Rc as well as Rb1 and Re can also inhibit coronary vascular dysfunction ( Hypertension There is substantial evidence that ginsenosides are beneficial in the treatment of hypertension, not only does ginseng lower blood pressure, it also acts as a heart protector (Nagar et al., 2016)