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Iron overload may also deplete both GSH (reduced glutathione) and methyl donors, which are required for maintaining normal DNA methylation patterns (Ye et al., 2019), which could indirectly alter neurotransmission signaling pathways, thereby influencing mood and behavior

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The diversity of mitochondrial functions is exquisitely balanced, but this balance is easy to break and can rapidly lead to apoptosis, necrosis, ROS explosion, and various cellular abnormalities (Figure 2B)