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Yes, brain shrinkage (termed cerebral atrophy in the research)

Metabolic endotoxemia, characterized by elevated levels of LPS in the bloodstream, is correlated with insulin resistance, increased adiposity, and a heightened risk of MetS and obesity [185, 186]

Senescent cells within the tumor microenvironment secrete a cascade of proinflammatory factors that promote tumorigenesis by inducing epigenetic instability, increasing cell proliferation, and stimulating angiogenesis