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While melatonin is no magic bullet for aging, in combination with chrononutrition and healthy lifestyle practices, it represents a powerful leverage point to promote healthy aging

For instance, curcumin inhibits NFB signaling by preventing IB degradation and subsequent nuclear translocation of NFB subunits, thereby suppressing the expression of proinflammatory cytokines such as TNF, IL1, and IL6 (Fuloria et al

2014 Aug 15;289(33):23065-74

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Specifically, the protein NGAL, in conjunction with iron and metformin, forms complexes that drive neutrophil infiltration into the kidneys, ultimately leading to NETosis and worsening AKI