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EP4 deficiency effectively attenuates the phagocytic state of microglia, disrupts cross talk with pro-opiomelanocortin (POMC) neurons, and results in an increased density of POMC neurites extending into the paraventricular nucleus (PVN)

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TermannsenADClemmensenKKBThomsenJMNrgaardODazLJTorekovSSet al

Further, as Healthline points out, injectable B12 which is generally given in much higher dosages than what can be found in food and multivitamins has been associated with more commonplace side effects, minor as they may be