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In addition, up-regulated levels of glutathione reductase, catalyzing the reduction of glutathione disulfide to the sulfhydryl form glutathione (a critical molecule in resisting oxidative stress and maintaining the reducing environment of the cell) may increase DPGs capacity for coping with the oxidative stress that accompanies HS

The increased time of fecal contents in the intestines results in excessive absorption of water and sodium from fecal contents, resulting in harder, drier stools and constipation

This overproduction can be triggered by UV exposure, inflammation, and hormonal changes all processes worsened by oxidative damage

doi: 10.1155/2013/638043 107 LiC.TangX.ZhengX.GeS.WenH.LinX.et al