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Exp Neurol 213:448455 Abe K, Aoki M, Tsuji S et al (2017) Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

1 Introduction Developing from an intramembranous or endochondral ossification process, bone is an essential structural and endocrine organ, with highly metabolic process that undergoes continuous reconstruction from bone formation and resorption ( Building targeting strategies based on pathogenesis has become an established paradigm for the development of implants and delivery systems