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Rats were assessed for fine motoric impairment with modified Irvine, Beatties and Bresnahan forelimb scale (IBB scale) that can detect recovery of both proximal and distal forelimb function including digit movements during a naturally occurring behavior that does not require extensive training or deprivation to enhance motivation (64)

Mild signs of hypersensitivity: itching or rash

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Therefore, tissue engineering is undoubtedly a key focus for future research and has the potential to fundamentally change the treatment paradigm for intervertebral disc degeneration