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Future efforts should prioritize combinatorial strategies that integrate metabolite modulation with immunotherapies, such as using engineered probiotics for localized butyrate delivery or ammonia-scavenging nanoparticles to alleviate T-cell exhaustion

Brown algae possess a notable affinity for heavy metals, enabling them to form stable metal complexes via transition-metal chelation

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Retatrutide may become the high-efficacy benchmark if Phase 3 and regulatory review support the early signal

A simplified schematic of the neuroanatomy of the Luschka nerve and discogenic pain pathways is shown in Fig