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doi: 10.1016/j.scitotenv.2013.03.083 198 ZakyA

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Under in vitro conditions, disruption of Syns tertiary ensemblesthrough charge neutralization (acidic pH or Ca 2+ addition), C-terminal truncation, or Syn-S129p could expose the hydrophobic (NAC) region and transform it into a metastable, reactive state 15,68