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Glutaminase is actively expressed in periportal liver cells, renal epithelial cells, and the central nervous system, which is used to synthesize urea and neurotransmitters

Indeed, increased NOX activity has been linked with AD progression and individuals converting from cognitively intact to dementia status (148)

NO itself is a source of cytotoxic molecules, and its deleterious effects are enhanced by its ability to concentrate locally around tumor cells and the tumor microenvironment