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Blood gets shunted away from non-essential organs (kidneys, gut, skin) and routed toward heart and brain

Tested substances were administered for 3 weeks (chemotherapy) or 40 days (DKFZ-608)

All these render RBCs as a sink or transporter for metabolites and signaling molecules, informatively demonstrated in the case of cortisol and aldosterone, both of which seem to be bound and released in a temperature-dependent manner (Papadopoulos et al., 2021b)

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NNMT in Cardiovascular Disease 5-Amino-1MQ as a Research Tool (MDPI, 2025) NNMT Inhibition as a Strategy for Cardiovascular Metabolic Pathway Research A 2025 review published in Biomolecules (MDPI) examined NNMT as a metabolic regulator in cardiovascular disease pathogenesis and identified 5-Amino-1MQ as a key research tool for investigating NNMT-mediated cardiovascular metabolic pathways