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In contrast, knock down of Nrf2 suppresses tumor growth, inhibits cell proliferation and promotes increased apoptosis [44, 49]

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Indeed, inhibition of enzymatic antioxidants and accumulation of excess levels of ROS generate OS in the ovary that directly affects oocyte quality and thereby reproductive outcome[10,14,64,65]

Its unique biochemical stability, targeted tissue uptake, and capacity to limit oxidative and metal-mediated damage distinguish it from many conventional antioxidants