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J Cell Physiol 169 : 175185

Retatrutide is engineered to activate three different receptors that all influence metabolism: GLP-1 receptor the target of semaglutide

DOI: 10.1210/endrev/bnad019 Imai S & Guarente L (2014) Trends in Cell Biology , 24(8): 464471 (npj Aging) Foundational review confirming the intimate connection between NAD+ availability and sirtuin activity as a conserved ageing/longevity regulatory axis