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Direct immunomodulatory effects on CD4 + T lymphocytes, enhancing regulatory T cell (Treg: CD4 + , CD25 + , FoxP3 + ) differentiation while suppressing Th1-mediated gonadal WAT (gWAT) inflammation

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PLoS One 14 , e0222158 (2019)

Pajarillo, E., Rizor, A., Lee, J., Aschner, M

5.11 Stiff-person syndrome A 69-year-old female with a 9-year history of treatment-refractory stiff-person syndrome, characterized by deteriorating episodes of stiffness, received an infusion of autologous anti-CD19 CAR T cells (KYV-101), resulting in a reduction of GABAergic medication, as well as improvements in leg stiffness, gait, walking speed, and daily walking distance (138)