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Csp1 has also been regulated in the fat bodies of queens inseminated with 8 l of either saline or semen compared to virgins 41 , upregulated in the brains of queens that were physically manipulated and exposed to CO 2 as compared to virgin queens 40 , and, according to three individual studies, upregulated in the brains of mated queens as compared to virgin queens 37,38,39 (Supplemental Table S6)