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Continuous use without breaks can reduce receptor sensitivity and potentially cause copper dysregulation

Reference: ARA16 ARA 290 16mg ARA-290 (aka Cibinetide) is a synthetic peptide derived from erythropoietin (EPO) designed to activate the innate repair receptor (IRR) and produce anti-inflammatory, neuroprotective, and tissue-repair effects without EPOs red bood-cell-stimulating or pro-thrombotic actions

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It reflects the threshold where copper peptides demonstrate follicle-stimulating activity without triggering the inflammatory cascade that copper overload produces

Stress is known to cause immune system dysfunction as it hyperactivates some aspects of immunity while suppressing others, resulting in immune disorders and allergies, which further increase stress on the organism