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Whole wounds of 6 mm in diameter were created within an ischaemic bicuspid flap on the back of each rat

337 The MSU crystals are initially engulfed by macrophages, which then facilitate the assembly and activation of the NLRP3 inflammasome, preceded by priming through pathways that activate NF-B, such as those initiated by the engagement of Toll-like receptors (TLRs) within the TLR family

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The evidence base is almost entirely preclinical: rodent models consistently show accelerated tissue repair, gut healing, and neurological protection, but human RCT data remains largely absent