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Free Radic Biol Med 1993

Polyamine metabolism and necroptosis associate with increased survival of humans with cancer To identify links between polyamine metabolism, necroptosis, and cancer prognosis, we analyzed survival data from patients with cancer, stratified by the expression levels of necroptosis-related molecules RIPK3 and MLKL, and enzymes involved in polyamine metabolism

366,367 In earlier clinical studies, the suitability of the population for intensified treatment remains unclear, with inconsistent intensity and duration of CDK4/6 inhibitors and inadequate management of their toxic side effects