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Chirgadze et al., 1999)

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Telomerase activity has been extensively explored as the telomere length maintenance mechanism that can be manipulated to increase longevity

NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994