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Results HGT1 overexpression causes toxic accumulation of GSH Hgt1 is an exclusive GSH and GSSG transporter (Bourbouloux et al , 2000)

10.1038/s41586-019-1103-9 22 BermanH

MicroRNA-218 increases the sensitivity of bladder cancer to cisplatin by targeting Glut1

588,589 -syn is functionally associated with iron, calcium, and lipid metabolism, and its aggregation has been found to induce ferroptosis by interacting with cellular membrane and accelerating lipid peroxidation

ACSL4 catalyzes the attachment of free PUFAs to coenzyme A to generate PUFA-CoAs, which are re-esterified and incorporated into phospholipids (PLs) by LPCAT3 to form PUFA-containing phospholipids (PUFA-PLs) ( The downregulation of PUFAs in tumour cells is associated with ferroptosis evasion and the promotion of tumour growth (Figure 1