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ROS trigger apoptosis by activating the pro-apoptotic proteins caspase-3/7/9 and cleaved PARP, disrupting mitochondrial function, and in pancreatic cancer melatonin-induced ROS enhance apoptosis through the mitochondrial pathway (Florido et al., 2022b)

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The more a food is cooked or processed, the faster it loses the important glutathione precursors