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At the beginning of pregnancy, low vitamin B12 levels can increase the risk of neural tube defects

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In murine models, NNMT knockdown did not induce the accumulation of NAM in livers and adipose tissues, nor did it cause significant alterations in the intracellular levels of NAD + in hepatocytes ( + is not necessary for this regulatory process

No significant statistical differences were observed in the basal levels of serum folate, HCY, and B12 among individuals with VCD, those who had recovered from the impairment, and non-impaired individuals, as detailed in Additional file 3

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