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These findings demonstrate that FAO disorders directly impair mitochondrial architecture and energy coupling in the failing heart

Initial doses of 125-250 mcg daily allow assessment of individual response and tolerance

Despite encouraging preclinical data, translating GPR109A-targeted therapies into clinical practice requires further investigation

Subsequently, the released ferrous/iron ions will react with excess hydrogen peroxide in the cell to produce a Fenton-like reaction generating hydroxyl free radicals (OH), and induce ferroptosis of tumor cells [205]