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This novel approach boasts three significant advantages over conventional therapeutic modalities: namely, long-term efficacy, a reduced incidence of adverse effects, and the capacity to address tumour heterogeneity

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and (ii) off-target resistance caused by the activation of bypass signal transduction resulting from the amplification of the ERBB family of receptor tyrosine kinase genes, BRAF amplification, KRAS amplification, and KRAS mutations [148]

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doi: 10.1111/j.1753-4887.1998.tb01670.x 10 GuoYBrunoRS