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10.1186/s13229-017-0116-1 308 Wood-DownieH.WongB.KovshoffH.MandyW.HullL

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the US EPA still does not know much about the health effects of poor water quality, noting that factors that can influence whether a contaminant will lead to health effects include the type of contaminant, its concentration in the water, individual susceptibility, the amount of water consumed, and the duration of exposure (2020)

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Metformin is a diabetes medication that can also reduce the absorption of vitamin B12 and potentially reduce serum vitamin B12 levels