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Study 2: Selective Small-Molecule Inhibitors (including 5-Amino-1MQ) A selective, membrane-permeable NNMT inhibitor series decreased intracellular 1-MNA, increased NAD and SAM, suppressed adipocyte lipogenesis, and reversed high-fat-diet obesity in mice

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CD38 has emerged as a major driver of age-related NAD + decline underlying adverse metabolic states, frailty and reduced health span

Washington (DC): National Academies Press