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Kefir peptides (KPs) provide organ-specific protection, including renal and joint tissues, by reducing oxidative stress, suppressing VCAM-1, MCP-1, ET-1, NLRP3, and TGF-, and enhancing antioxidant defenses such as superoxide dismutase (SOD) activity (Chen et al., 2019, 2020)

Sethumadhavan S, Chinnakannu P: L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle

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TCM also mitigates subjective symptoms (fatigue, edema) unaddressed by conventional therapies and poses lower risks of hypotension/electrolyte disorders, even in advanced CKD ( 4.2 Nutrient-sensing mechanisms: Key players in DKD pathogenesis While malnutrition is indeed a secondary manifestation of metabolic and renal dysfunction, nutrient sensing dysregulation (e.g., via AMPK/SIRT1/mTORC1 pathways) constitutes a pivotal mechanism in DKD progression, deeply intertwined with oxidative stress and autophagy impairment