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With a vitamin B12 deficiency comes the risk of suffering from megaloblastic anemia, including symptoms of fatigue, weakness, pale skin, lack of appetite, infertility, and unexplained weight loss

Anti-Inflammatory Local Effect of Hydroxytyrosol Combined with Pectin-Alginate and Olive Oil on Trinitrobenzene Sulfonic Acid-Induced Colitis in Wistar Rats

Zetterman T, Markkula R, Partanen JV, Miettinen T, Estlander AM,Kalso E

And you should do that on a regular basis, because your body doesnt store vitamin B12 for a long time

However, clinical trial data specifically on tirzepatide + B12 are not available, and individual responses vary by individual