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Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer

Islam S, Islam MM, Akhand MRN, Park BY, Akanda MR

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Consequently, CD38 deficiency elevated SIRT1 and SIRT3 activities by increasing intracellular NAD + levels, thus reestablishing mitochondrial and lysosomal functions to inhibit generation of senescence-associated small extracellular vesicles and acquisition of senescence-associated secretory phenotypes in mice with angiotensin II-induced vascular smooth muscle cell senescence and vascular remodeling [69]